Biofilm Formation Μm Effect Bioactivity Surface Ratio
alpha'-dicarboxylic acid
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Statistical Optimization of As(V) Adsorption Parameters onto Epichlorohydrin/Fe3O4 Crosslinked Chitosan Derivative Nanocomposite using Box-Behnken Design.In this study, Box-Behnken design (BBD) in response surface methodology (RSM) was employed to optimize As(V) removal from an aqueous solution onto synthesized crosslinked carboxymethylchitosan-epichlorohydrin/Fe3O4 nanaocomposite. The genes like solution pH, adsorbent dose, contact time and temperature were optimized by the method which shows high correlation coefficient (R2=0), and a predictive quadratic polynomial model equation. The adequacy of the model and arguments were valued by analysis of variance (ANOVA) with their significant brokers of Fischer's F - test (p<0). Seven significant parameters with interaction outcomes in the experiment with p-value < 0 was observed, consuming a maximum removal efficiency of As(V) is 95%. Optimal conditions of dosage, pH, temperature, initial ion concentration and contact time in the process were seed to be 0 g, pH 6, 308K, 10 mg/L and 60 min respectively.
Langmuir isotherm model fitted better than the Freundlich model having a maximum adsorption capacity of 28 mg/g, a high regression value of 0, least chi-square value of 0. The process was found to follow monolayer adsorption and pseudo-second-order kinetics. Thermodynamic parameters indicate the process is spontaneous, endothermic and physisorption in nature. Successful regeneration of the adsorbent incriminates its applicability to the removal of arsenic from real life wastewater.Glutaraldehyde-crosslinked chitosan-polyethylene oxide nanofibers as a potential gastroretentive delivery system of nizatidine for augmented gastroprotective activity.Nizatidine (NIZ), a histamine H(2)-receptor antagonist, is soluble and stable in the stomach, however, it exhibits a short half-life and a rapid clearance. Therefore, chitosan (CS) and polyethylene oxide (PEO) nanofibers (NFs) at different weight proportions were machinated by electrospinning and qualifyed.
The selected uncrosslinked and glutaraldehyde-crosslinked NFs were investigated sing swiming, solid-state features, in vitro release, and in vitro cytotoxicity. The cytoprotective activity against ethanol-hastened gastric injury in rats was measured through macroscopical, histopathological, immunohistochemical, and oxidative stress interrogations. NFs grinded on 8:2 CS:PEO showed the smallest diameter (119 ± 22 nm) and the greatest mucoadhesion (22 ± 3 g/cm(2)), so they were crosslinked with glutaraldehyde. Solid-state characterization designated polymers interaction, a successful crosslinking, and NIZ dispersion in NFs. Crosslinking sustained swollen mats at pH 1 (swelling% = 29 ± 3% at 24 h), decelerated their erosion at pH 6 (swelling%= 84 ± 4% vs. 25 ± 0% for the uncrosslinked NFs at 24 h), augmented the swiming up to 24 h vs. 10 min for the uncrosslinked NFs at pH 1 and protracted the drug release (%drug released ≥ 93% at 24 h vs.
4 and 5 h for the uncrosslinked NFs at pHs 1 and 6, respectively). The viability of Caco-2 cells ≥ 86 ± 6% unveiled NFs biocompatibility and unreacted glutaraldehyde removal. Crosslinking of 8:2 CS:PEO NFs potentiated the antiulcer activity (38 vs. 8 for the uncrosslinked NFs) as well as it upholded the gastric wall architecture, COX-2 expression, and oxidative stress marks points of the normal rats.Treatment of Critical-Size Femoral Bone mars with Chitosan Scaffolds Produced by a Novel Process from Textile Engineering.The purpose of this study was to investigate, in vitro and in vivo, the suitability of chitosan (CHS) scaffolds acquired by the net-shape-nonwoven (NSN) technology, for use as bone graft fill-ins in a critical-size femoral bone defect in rats. For in vitro probes, scaffolds made of CHS, mineralized collagen (MCM), or human cancellous bone allograft (CBA) were seeded with human telomerase-eternalised mesenchymal stromal cells (hTERT-MSC), covered for 14 days, and thereafter judged for proliferation and osteogenic differentiation.
In vivo, CHS, MCM and CBA scaffolds were embeded into 5 mm critical-size femoral bone flaws in rats.