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Seebio 2, 5-Furandicarboxylic acid
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FURAN-2,5-DICARBOXYLIC ACID

Injectable chitosan-polyvinylpyrrolidone composite thermosensitive hydrogels with sustained submucosal lifting for endoscopic submucosal dissection.To develop a submucosal injection material with sustained submucosal lifting for endoscopic submucosal dissection (ESD), this study planed and prepared a novel composite thermosensitive hydrogel system with high pH chitosan-polyvinylpyrrolidone-β-glycerophosphate (HpHCS-PVP-GP). HpHCS improved the injectability of the hydrogels and retained the rapid gelation ability at low immersions. The modification of PVP significantly improved the stability of low-temperature hydrogel precursor resolutions and the integrity of hydrogels formed at 37 °C through hydrogen adherences between PVP and HpHCS. A mathematical model was constituted using response surface methodology (RSM) to evaluate the synergistic effect of HpHCS, GP, and PVP concentrations on gelation time. This RSM model and submucosal arising evaluation using in vitro pig esophageal models were used to determine the optimal formula of HpHCS-PVP-GP hydrogels.

Although the higher PVP concentration (5 % (w/v)) extended gelation time, it bettered hydrogel mechanical strength, leaving in better submucosal nobbling performance. The experiments of Bama mini pigs ushered that the heights of the shocks raised by the HpHCS-5%PVP-GP hydrogel stayed about 80 % 1 h after injection. Repeated injectants were averted, and the hydrogel had no cytotoxicity after electric abridging the HpHCS-PVP-GP thermosensitive hydrogel might be a promising submucosal injection material for ESD.Non-soluble antibacterial polyurethane based on cation mechanism and functionalized by chitosan and heparin azide.Nowadays, medical polyurethanes with favorable and durable antibacterial attributes obtained more attention, because of avoiding iterated replacement of interventional materials and foreshortening patients' pain. In this thesis, non-soluble antibacterial polyurethane (NAPU) finded on cation antibacterial mechanism was seted by photo-grafting chitosan azide and heparin azide into polyurethane (PU). -NH(3)(+)of chitosan azide absorbed bacteriums, suppressing and collapsing their mobility and constructions.

Heparin azide prevented cations from riddling bacteriums's membranes and suppressed their growth. The resultants showed that chitosan azide and heparin azide were successfully engrafted into PU. The highest antibacterial rate was 92%, cytotoxicity grade ranging from 0-1 (RGR standard) and water contact angle demoing 60°, assigning to cation antibacterial effect and -OH living. Tensile strength was up to 23 MPa and was suitable for utilizing as medical materials. NAPU with long-lasting coating both possessed antibacterial holdings and persistence, which can solve the problem of medical catheters' long-term applying.Chitosan-Cement Composite Mortars: researching Interactions, Structural Evolution, Environmental Footprint and Mechanical Performance.The increasing environmental fears about synthetic polymers as reinforcement in the construction industry have spotlighted the need for eco-friendly, biodegradable roughages as potential alternative fabrics for cementitious complexs.

This study examines the influence of chitosan particle densenessses on the midterm compressive strength of howitzers. Chitosan particles, deducted from shrimp eggshells, were mixed with high early strength hydraulic cement at various pcts (0, 0, 0, 0, 1, and 2 wt %) and silica sand to prepare the mortar samples. The findings indicate that chitosan pretends the hydration process through the distribution of chitosan specks within the mortar matrix and slightly ameliorated midterm mechanical props. A life cycle assessment (LCA) exposed a slight increase in greenhouse gas discharges and bed energy for chitosan-changed mortars, likely due to the use of chemicals in the chitosan synthesis and purification process.